Sam Patel is a globally experienced stem cell biologist specializing in precision and regenerative medicine, with a focus on translating advanced cellular engineering techniques into practical solutions. Over the course of his career, he has led preclinical drug discovery programs, developed disease models, and pioneered innovative approaches in personalized medicine using tools such as CRISPR/Cas9, iPSC technology, and optogenetics.
Sam has worked across world-class institutions and biotech companies, including Toronto, Heidelberg, Leuven, Los Angeles, and San Francisco, amassing a wealth of expertise in diverse research environments. At UCLA, he spearheaded research into neurodegenerative disease mechanisms, creating 3D organoid models integrated with astrocytes and microglia to study neuron-glial interactions. His time at Prolific Machines saw him leveraging cutting-edge bioreactor technology to develop scalable systems for biologics production and cell-based therapies.
Driven by a passion for impactful science, Sam is now dedicated to applying his experience toward solving complex challenges in policy-making, public health, and translational biotechnology. With a unique blend of scientific acumen, leadership experience, and a commitment to innovation, he strives to bridge the gap between research and real-world applications.
Outside the lab, Sam is an avid foodie exploring global cuisines and enjoys storytelling through writing, both of which reflect his curiosity and creative spirit.
Projects
Neuron-glial interface in neurodegeneration: An iPSC-derived organoid model
LLHF Principal Investigator: Dr. Sam Patel
Publications
Dystrophin deficiency leads to dysfunctional glutamate clearance in iPSC derived astrocytes
Abdulsamie M. Patel, Keimpe Wierda, Lieven Thorrez, Maaike van Putten, Jonathan De Smedt, Luis Ribeiro, Tine Tricot, Madhavsai Gajjar, Robin Duelen, Philip Van Damme, Liesbeth De Waele, Nathalie Goemans, Christa Tanganyika-de Winter, Domiziana Costamagna, Annemieke Aartsma-Rus, Hermine van Duyvenvoorde, Maurilio Sampaolesi, Gunnar M. Buyse, Catherine M. Verfaillie
Translational Psychiatry, vol. 9(1), 2019 Jul 20
HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients
Wenting Guo, Maximilian Naujock, Maximilian Naujock, Laura Fumagalli, Tijs Vandoorne, Pieter Baatsen, Ruben Boon, Laura Ordovás, Laura Ordovás, Abdulsamie Patel, Marc Welters, Thomas Vanwelden, Natasja Geens, Tine Tricot, Veronick Benoy, Jolien Steyaert, Cynthia Lefebvre-Omar, Werend Boesmans, Matthew Jarpe, Jared Sterneckert, Florian Wegner, Susanne Petri, Delphine Bohl, Pieter Vanden Berghe, Wim Robberecht, Philip Van Damme, Catherine Verfaillie, Ludo Van Den Bosch
Nature Communications, vol. 8(1), 2017 Sep 10, pp. 861-861
Kristina Lanko, Kristel Eggermont, Abdulsamie Patel, Suzanne Kaptein, Leen Delang, Catherine M. Verfaillie, Johan Neyts
Antiviral Research, vol. 145, 2017 Jul 31, pp. 82-86
Robin Duelen, Guillaume Gilbert, Abdulsamie Patel, Nathalie de Schaetzen, Liesbeth De Waele, Llewelyn Roderick, Karin R. Sipido, Catherine M. Verfaillie, Gunnar M. Buyse, Lieven Thorrez, Maurilio Sampaolesi
Stem Cells International, vol. 2017(2017), 2017 8, pp. 1-17
Edin Mujagic, Roberto Gianni-Barrera, Marianna Trani, Abdulsamie Patel, Lorenz Gürke, Michael Heberer, Thomas Wolff, Andrea Banfi
Human Gene Therapy Methods, vol. 24(1), 2013 28, pp. 28-37
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